无创肺功能研究系绞�/span>

全身体积描记系统（Whole Body Plethysmograph System）用于动物在清醒、无束缚状态下，测量动物的各项肺功能参数。该系统简单、易用、快速、数据输出量大的特点使其成为国外药企研发机构喜爱的研究工具，主要用于哮喘等新药研发过程中进行粗筛实验。其指标参数能够良好地反映动物对药物产生的气道高反应情况，适合于需要动物在*自然状态下呼吸的研究以及长期跟踪实验、�/span>

每个体描箱都具备雾化攻击、温湿度补偿接口，另外还具有供水接口和气体采样接口以适用于各种特殊需要的研究、�/span>

Whole body plethysmography is an application whereby ventilatory parameters are measured while the subject is conscious and unrestrained. By the use of bias airflow supplies� CO2 levels� temperature and humidity are maintained at normal levels enabling measurements to be made over several hours.

During inspiration there is a slight net pressure rise within theplethysmograph due to increased temperature and humidity of the air as it enters the subject’s lungs (gas conditioning). During normal breathing� this pressure difference is directly proportional to the respiratory pattern of the subject� allowing the researcher to measure respiratory rate and tidal volume� in accordance with ICH S7 Guidelines.

The system is commonly used in airway hyper-reactivity studieswhere� in addition to changes in ventilatory parameters� valuable data can obtained

by quantifying changes in the shape of the respiratory waveform� e.g.� Penh. However� it should be noted that when bronchoconstriction is present�

the respiratory signal is dominated by the effects of gas compression and therefore exact measures of tidal volume can not be determined.

Parameters Measured

�� Breathing frequency

�� Tidal volume (during normal breathing)

�� Minute volume

�� Penh (enhanced pause)

�� Inspiration time

�� Expiration time

�� Peak inspiratory flow

�� Peak expiratory flow

�� Explanation and more parameters

Features

�� Non-invasive

�� Real time tidal volume measurement using multiple compensation factors (e.g. Epstein & Epstein� Drorbaugh & Fenn)

�� Real time environmental monitoring (atmospheric pressure� temperature� humidity)

�� Subject is unrestrained and conscious

�� No anaesthesia

�� Range of species including guinea pigs� rats and mice

�� Chronic and long term use

�� Measurement during aerosol challenge

��Up to sixteen animals measured simultaneously

�� Optional body temperature measurement through telemetry

Uses

�� Airway hyper-reactivity models

�� Late phase response studies

�� Chronic studies

�� Drug screening

�� Toxicology

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