动物无创全身体积描记系统/无创型动物肺功能检测仪

WBP清醒无约束动物气道高反应检测系� (Conscious� Unrestrained� Non-invasive)

?无须麻醉的无创检测方法，动物清醒并可自由活动�

?操作简单方便，可同时检测数十只动物，适合于大量筛选实验；

?尤其适用于长期跟踪研究，同只动物多次重复实验�

?提供呼吸速率、潮气量、呼气峰值、吸气峰值、Penh等参数；

?提供从啮齿类到非人灵长类动物的各种全身体积描记器、�/span>

无创型动物肺功能检测系�?全身体积描记�?/span>

Whole body plethysmography is an application whereby ventilatory parameters are measured while the subject is conscious and unrestrained. By the use of bias airflow supplies� CO2 levels� temperature and humidity are maintained at normal levels enabling measurements to be made over several hours.

During inspiration there is a slight net pressure rise within theplethysmograph due to increased temperature and humidity of the air as it enters the subject’s lungs (gas conditioning). During normal breathing� this pressure difference is directly proportional to the respiratory pattern of the subject� allowing the researcher to measure respiratory rate and tidal volume� in accordance with ICH S7 Guidelines.

The system is commonly used in airway hyper-reactivity studieswhere� in addition to changes in ventilatory parameters� valuable data can obtained

by quantifying changes in the shape of the respiratory waveform� e.g.� Penh. However� it should be noted that when bronchoconstriction is present�

the respiratory signal is dominated by the effects of gas compression and therefore exact measures of tidal volume can not be determined.

Parameters Measured

�� Breathing frequency

�� Tidal volume (during normal breathing)

�� Minute volume

�� Penh (enhanced pause)

�� Inspiration time

�� Expiration time

�� Peak inspiratory flow

�� Peak expiratory flow

�� Explanation and more parameters

Features

�� Non-invasive

�� Real time tidal volume measurement using multiple compensation factors (e.g. Epstein & Epstein� Drorbaugh & Fenn)

�� Real time environmental monitoring (atmospheric pressure� temperature� humidity)

�� Subject is unrestrained and conscious

�� No anaesthesia

�� Range of species including guinea pigs� rats and mice

�� Chronic and long term use

�� Measurement during aerosol challenge

��Up to sixteen animals measured simultaneously

�� Optional body temperature measurement through telemetry

Uses

�� Airway hyper-reactivity models

�� Late phase response studies

�� Chronic studies

�� Drug screening

�� Toxicology

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