The VenaT4? biochip is the only biochip available for studying chemotaxis� transmigration and invasion assays and is Cellix's new microflow transwell chamber.

VenaT4?趋化性研究芯牆�/strong>是Cellix推出的一种新型Transwell室，可以用来进行趋化（chemotaxis）、迁�?transmigration)、侵袭（invasion）研究、�/span>

The VenaT4TM biochip model combines Cellix's proprietary microfluidic flow technology for cell recruitment under shear stress with traditional transwell chamber models. Used to investigate and quantify cell recruitment to various ligands in the presence of chemoattractants contained within the microwells mimicking tissue and / or injury sites.

趋化性研究芯牆�/strong>结合Cellix专有的微流体技术，用于研究在剪切力下细胞的聚集。利用微孔模拟组织和/或伤口，微孔包覆化学引诱物，用于研究和量化细胞对各种配体的聚集、�/span>

The biochips contain 4 microcapillaries in parallel� each with an embedded microporous membrane with pores of 2-10um diameter (depending on application). Underneath each membrane is a microwell. See image above. The microcapillaries of the VenaT4TMbiochips are easily coated with ECM proteins using a standard yellow-tip pipette� giving the researcher greater flexibility. The VenaT4TM biochip is suitable for the following assays:

Chemotaxis Assays: Cells flowing through the microcapillary of the biochip may attach to the protein coated membrane and migrate towards the chemokine in the underlying microwell.

趋化性实验：细胞流经微流道，可能与膜上的蛋白涂布粘附，然后向底层的趋化因子迁移、�/span>

Transmigration Assays: Cells flowing through the microcapillary of the biochip may attach to the cell monolayer on the membrane and transmigrate through the cell monolayer and membrane towards the chemokine in the underlying microwell.

迁移实验：细胞流经微流道，可能与膜上的单个细胞粘附，然后穿过细胞核膜，向底层的趋化因子迁移、�/span>

Invasion Assays: Cells flowing through the microcapillary of the biochip may attach to the cell monolayer on the membrane and transmigrate through the cell monolayer and membrane into a 3D ECM in the underlying microwell.

侵袭实验：细胞流经微流道，可能与膜上的单个细胞粘附，然后穿过细胞核膜，向底层�?D ECM迁移、�/span>

The VenaT4TM biochip is suitable for use with the following:

Cell types: Leukocytes� neutrophils� lymphocytes� macrophages� monocytes� endothelial cells� epithelial cells� fibroblasts and tumour cells.

细胞种类：白细胞、中性粒细胞、淋巴细胞、巨噬细胞、单核细胞、内皮细胞、上皮细胞、成纤维细胞和肿瘤细胞、�/span>

Coatings: collagen� fibronectin� laminin etc.

涂布：胶原、纤连蛋白、层粘连蛋白筈�/span>

产品特点９�/strong>

* 适合白细胞和癌症细胞的迁移、侵袭和趋化性实验（migration� transmigration� invasion and chemotax（�/span>

* 可以进行全血和血细胞分析（如白细胞）

* 聚碳酸酯膜，空隙大小�?-10��m、�/span>

* 每个芯片�?个微流道，每个容量仅14��L。可以将化学引诱物固定在基质胶（ECM gel）里靡�/span>

* 配合Kima泵使用，可进行长期的迁移研究

* 利用MirusTM Nanopump可以提供并控�?.05�?00 dyne/cm2的流体剪切力，剪切流可为脉冲流或平稳流、�/span>

* 在流体剪切力环境下，实时成像、实时观寞�/span>

* 可使用明�?相称/荧光显微镜，20x� 40x长工作距离显微镜下观察，芯片光学性能良好

请关注Cellix公司独特的微流体技术：

* 全面的微流体方案，提�?接近生理环境的流体剪切力

* Lab on a Chip，节省样本，可实时观寞�/span>

* 细胞粘附、迁移、趋化性研究的新手段，新思路

剪切力细胞分析系绞�/strong>

剪切力细胞分析系统能提供接近生理血流状态下的剪切流，逼真模拟人体生理环境，适用于细胞滚动、粘附和迁移的研究，并且能够实现高通量细胞分析。目前已广泛应用于心血管疾病、肿瘤、传染性疾病、呼吸道、免疫学及细菌学等领域�