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动物实验仪器
分子生物学仪?/a>
甩尾测痛?/strong>仪器简介:
甩尾测痛仪主要是用于测量大、小鼠尾巴部受红外热刺激的痛觉阈值。实验时,当动物感觉疼痛,尾巴会轻敲台面,内置传感器会立刻检测到,停止计时和关闭光源,即仪器自动记录反应时间和光源强度。数据可通过U盘、USB数据线等导出、/span>
甩尾测痛仪的详细介绍
甩尾测痛仪主要是用于测量大、小鼠尾巴部受红外热刺激的痛觉阈值。实验时,当动物感觉疼痛,尾巴会轻敲台面,内置传感器会立刻检测到,停止计时和关闭光源,即仪器自动记录反应时间和光源强度。数据可通过U盘、USB数据线等导出、/span>
甩尾测痛仪中有一可调强度的红外光源,其红外光主要是通过一抛物面反射镜聚焦在实验动物的尾巴上。实验时,操作人员将实验动物置于仪器上,把动物的尾巴放在红外光源处,接受刺激、/p>
特征
仪器自动记录实验数据
精度高,避免人为因素引起的误?/p>
包含U盘和软件
优点可独立工作,也可连接电脑使用
仪器工作台表面无突出和遮挡物仵/p>
操作方便,实验重复性好
规格:/p>
命令9/span>软键和脚踏板连接电脑9/span>DELTA 9-pin连接头,USB连线
数据读取:液晶显礹/p>
电源:universal mains 85-264 VAC 50-60Hz
打印:微型热敏打印机(需另外购买(/p>
工作温度?5 - 30 C
开始:红外开兲/p>
声级9 70 dB
红外强度?0-99级间可调
反应时间:液晶屏显示,分辨率?.1s
校准:红外热辐射计(需另外购买(/p>
截止时间:预置,15 - 60 s闳/p>
文献
关于方法
- F.E. D’Amour & D.L. Smith: "A Method for Determining Loss of Pain Sensation." J. Pharmacol. Exp. Therap. 72: 74-79 1941.
- D.C. Yeomans & H.K. Proudfit: “Characterization of the Foot Withdrawal Response to Noxious Radiant Heat in the Rat”Pain 59: 85-97 1994.
涉及疼痛甩尾
- C. Dawson et alia: Dexmedetomidine Enhances Analgesic Action of Nitrous Oxide Anesthesiology 100 (4): 894?904 2004
- P. Tolu et alia: Effects of Long-Term Acetyl-L-carnitine Administation in Rats: I. Increased Dopamine Output in Mesocorticolimbic Areas and Protection Toward Acute Stress Exposure Neuropsychopharmacol. 27 (3): 410-420 2002
- R. Nadeson et alia: Potentiation by Ketamine of Fentanyl Antinociception. I. An Experimental Study in Rats Showing that Ketamine Administered by Non-Spinal Routes Targets Spinal Cord Antinociceptive Systems Br. J. Anaesthesia 88 (5): 685?691 2002
- L. Jasmin et alia: The NK1 Receptor mediates Both the Hyperalgesia and the Resistance to Morphine in Mice Lacking Noradrenaline PNAS 99 (2): 1029?1034 2002
- G.L. Fraser et alia: Antihyperalgesic Effects of Opioid Agonists in a Rat Model of Chronic Inflammation Br. J. Pharmacol. 129: 1668?1672 2000
- M. Xu et alia: Effects of Radolmidine a Novel 2- Adrenergic Agonist Compared with Dexmedetomidine in Different Pain Models in the Rat Anesthesiology 93 (2): 473?481 2000
- A. K?ster et alia: “Targeted Disruption of the Orphanin Fq/Nociceptin Gene Increases Stress Susceptibility and Impairs Stress Adaptation In Mice Neurobiology 96 (18): 10444-10449 1999
- I. Sora et alia: “Opiate Receptor Knockout Mice Define Receptor Roles in Endogenous Nociceptive Responses and Morphine-Induced Analgesia Neurobiology 94: 1544-1549 1997
- C.T. Dourish et alia: "The Selective CCK-B Receptor Antagonist L-365?60 Enhances Morphine Analgesia and Prevents Morphine Tolerance in the Rat" Europ. J. Pharmacol. 176: 35-44 1990
- P.W. Nance & J. Sawinok: "Substance P-Induced Long-Term Blockade of Spinal Adrenergic Analgesia: Reversal by Morphine and Naloxone" J. Pharmacol. Exp. Therap. Vol. 240 No. 3: 972-977
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