Randall-Selitto痛觉测试�?/strong>简单介�

Randall-Selitto痛觉测试�?/strong>适用于大小鼠机械痛耐受检测，设备覆盖学科包括神经生物学、神经药理学、神经病学、麻醉科学、康复科学和中西医结合学科、�/p>?

Randall-Selitto痛觉测试�?/strong>的详细介绌�/p>

产品品牌：意大利UGO

产品型号�?7215

Randall-Selitto痛觉测试�?/strong>根据Randall-Selitto理论设计，是进行压爪实验的经典仪器。实验时，将啮齿类动物的爪置于圆柱形底座，操作员踩压脚踏板，其上方的圆锥形推进器往爪上施力。当受试动物开始挣扎时，操作员松开脚踏板板，读取刻度值，其表示受试动物的疼痛值。压痛仪的显著特征是配备了一个低电压同步电动机、�/span>

该实验常用于止痛药和消炎药的快速筛选、�/p>

牸�strong>Randall-Selitto痛觉测试�?/strong>�?/strong>

基于力学原理的压力增强设讠�/p>

持久可靠，不需校准

双面压力� (钝、锥�?

优点

压力增强范围� (0-750 g)

可用于发炎和非发炎的�?/p>

用于不同实验

产品规格９�/strong>

**力倻�750 g

力增加速率:16 g/s (加一个砝码时�?6x2 g/s� 加两个砝码时�?6x3g/s)

刻度分辨玆�5 g (加一个砝码时�?x2g� 加两个砝码时�?x3g)

电源要求�?15�?30V�?0/60 Hz�?*15 W

参考文献：

关于方法

�� L.O. Randall and J.J. Selitto: “A Method for Measurement of Analgesic Activity on Inflamed Tissue� Arch. Int. Pharmacodyn. CXI� No. 4: 409-419� 1957.

涉及压痛仪（大鼠（�/p>

�� K. Walker et alia: “The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain� J. Pharmacol. Exper. Therap. 304� No. 1: 56-62� 2003.

�� S. Asfaha et alia: “Proteinase-Activated Receptor-1 Agonists attenuate nociception in Response to Noxious Stimuli� Br. J. Pharmacol. 135: 1101-1106� 2002.

�� K.O. Aley et alia: “Chronic Hypersensitivity for Inflammatory Nociceptor sensitization Mediated by the ?Isozyme of Protein Kinase C� J. Neuroscience 20 (12): 4680-4685� 2000.

�� O.A. Kochuvelikakam and J.D. Levine: “Role of Protein Kinase A in the Maintenance of Inflammatory Pain� J. Neuroscience. 19(6): 2181-2186� 1999.

涉及压痛仪（小鼠（�/em>

�� H. Saegusa et alia: “Suppression of Inflammatory and Neuropathic Pain Symptoms in Mice Lacking the N-type Ca2+ Channel� The EMBO Journal. 20� No. 10: 2349-2356� 2001.

�� W. Binder et alia: “Effect of Gender on Anti-Inflammatory and Analgesic Actions of Two ��-Opioids� J. Pharmacol. Exper. Therap. 292: 303-309� 2000.