爪肿测量�?/strong>仪器简介：

爪肿测量�?/strong>计用于测量抗肿药物的效果－�strong>爪肿测量�?/strong>使用方法简单，将肿胀的大鼠爪放入仪器的水槽中，导致水平面上升＋�strong>爪肿测量�?/strong>测量出水平面上升引起的水压力变化值，该压力变化值对应伸入水中肿胀大鼠爪的体积：�/span>

爪肿测量�?/strong>的详细介�

产品品牌：意大利UGO

产品型号�?7140

爪肿测量�?/strong>设计用于风湿关节炎、水肿、药理作用等研究，精确测量啮齿类动物肢体的肿胀情况。自上世�?0年代起，已经有超�?000篇的引文。该仪器是大、小鼠炎症水肿测量的理想工具，其测量分辨率是0.01ml、�/p>

爪肿测量�?/strong>整套仪器包含一个脚踏开关，用于记录读数，从而使得操作人员可以全神贯注于将动物的爪侵没于测量水杯中。液晶屏实时显示实验数据，通过相应软件可方便的将实验数据导入电脑、�/p>

爪肿测量�?/strong>使用方法简单，将肿胀的大鼠爪放入仪器的水槽中，导致水平面上升＋�strong>爪肿测量�?/strong>测量出水平面上升引起的水压力变化值，该压力变化值对应伸入水中肿胀大鼠爪的体积；对大鼠服用抗肿胀药物，大鼠的爪相应消肿，将消肿的大鼠爪放入水槽中，导致水平面上升＋�strong>爪肿测量�?/strong>测量出水平面上升引起的水压力变化值，该压力变化值对应伸入水中消肿大鼠爪的体积，根据两次水压力变化值即体积的差值评估得出抗肿胀药物的效果、�/p>

特征

脚踏记录实验数据

超过1000引文

多测量水杯可逈�/p>

优点

免手持操佛�/p>

绝大多数应用开在参考文献中查到

可用于大、小鼠实骋�/p>

规格参数９�/strong>

测量水杯直径�?.3 cm (小鼠)� 1.8; 2.5 & 3.5 cm (大鼠)

读数分别率：0.01ml

与电脑连接：串行接口或USB接口

软件：包含在标配�?/p>

参考文献：

et alia: “A2A Adenosine Receptors Are Differentially Modulated by Pharmacological Treatments in RheumatoidArthritis Patients and Their Stimulation Ameliorates Adjuvant-Induced Arthritis in Rats�PLoS ONE8(1): e54195� 2013

��T. Bertaim et alia: “Dose and Administration Schedule Effect of Tiludronate on Joint Damage in the Model of Complete Freund Adjuvant Induced Monoarthritis in Rats�Open Journal of Rheumatology and Autoimmune Diseases3: 18-25� 2013

��E. Borb��ly et alia: “Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse� PLoS ONE 8(4): e61684�?013

......

��R. Korhonen et alia: ‛�span>Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1�Br. J. Pharmacol. 169 (7):1525-1536� 2013

��A. Finlay et alia: “Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism� PLoSONE8(1): e55255� 2013.....

��D. Piomelli et alia:� Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism�? Nature NSC�2010

��L.H. Santos et alia: "Anti-Inflammatory� antinociceptive and Ulcerogenic Activity of a Zinc-Diclofenac Complex in Rats" Brazil. J. Med. Biol. Res. 37: 1205-1213� 2004

��D.W. Li et alia: "Antiinflammatory Activity of a ��-Hederin methyl Ester from the Alkaline Hydrolysate of the Butanol Fraction ofKalopanax PictusBark Extract" Biol. Pharm. Bull. 26 (4): 429-433� 2003

��A. Rotelli et alia: “Comparative Study of Flavonoids in Experimental Models of Inflammation� Pharmacol. Research 48: 601-606� 2003

��H. Machelska et alia: "Opioid Control of Inflammatory Pain Regulated by Intercellular Adhesion Molecule-1" J. Neuroscience 22 (13)� 5588-5596� 2002

��W. Binder & J. Walker: "Effect of the Peripherally Selective ��-Opioid Agonist� Asimadoline� on Adjuvant Arthritis" Br. J. Pharmacol. 124: 647-654� 1998

��F. Vincenzi