搴旂敤
搴旂敤
搴旂敤
搴旂敤
鑳屾櫙:浜哄伐鍚堟垚鐨勭７閰搁挋闄剁摲鏉愭枡涓庡ぉ鐒堕缁勭粐鏃犳満鎴愬垎鐩镐技,閫氳繃琛ㄩ潰褰㈣矊鍜屽寲瀛︾粍鎴愯繘琛屽姛鑳藉寲璁捐鍙祴浜堝叾浼樺紓鐨勯浼犲鍜岄璇卞鎬ц兘,鐮斿彂鍏锋湁楠ㄨ瀵兼€ц兘鐨勭７閰搁挋闄剁摲鏉愭枡鏄洰鍓嶇殑鐮旂┒鐑偣銆傜洰鐨凓閫氳繃鏉愭枡褰㈣矊璋冩帶鍜屽姛鑳藉寲璁捐璧嬩簣浜氬井绫虫嫇鎵戠粨鏋勭７閰镐笁閽欓櫠鐡烽璇卞鎬ц兘,妫€娴嬪叾鐞嗗寲鎬ц兘鍙婇璇卞鎬ц兘銆傛柟娉旡閲囩敤楂樻俯鐑х粨娉曞埗澶囦簹寰背鎷撴墤缁撴瀯鐨勭７閰镐笁閽欓櫠鐡?浠ュ競鍦哄彲渚涘晢鍝佸寲鐨勯淇鏉愭枡Bio-Oss楠ㄧ矇涓哄鐓х粍,琛ㄥ緛涓ょ鏉愭枡鐨勮〃闈㈠舰璨屻€佽泲鐧藉惛闄勮兘鍔涘強浣撳鐭垮寲鎬ц兘銆傚皢绗?浠ｄ汉鐗欏懆鑶滃共缁嗚優涓庝袱绉嶆潗鏂欐蹈鎻愭恫鍏卞煿鍏?閲囩敤CCK-8娉曟娴嬬粏鑳炲娈?鑼滅礌绾㈡煋鑹叉娴嬬粏鑳炵熆鍖栨€ц兘;灏嗙3浠ｄ汉鐗欏懆鑶滃共缁嗚優鍒嗗埆鎺ョ鑷充袱绉嶆潗鏂欒〃闈?閲囩敤纰辨€х７閰搁叾鏌撹壊妫€娴嬫棭鏈熸垚楠?qR T-PCR妫€娴嬫垚楠ㄧ浉鍏冲洜瀛愮殑琛ㄨ揪銆傜粨鏋滀笌缁撹:(1)鎵弿鐢甸暅涓嬪彲瑙佷袱绉嶆潗鏂欏潎鍏锋湁棰楃矑鐘剁汗鐞嗙殑寰瓟琛ㄩ潰,Bio-Oss棰楃矑鏄庢樉灏忎簬纾烽吀涓夐挋闄剁摲,涓ょ鏉愭枡鐨勬€诲瓟闅欏害銆佸ぇ瀛旈殭搴﹀拰寰瓟闅欏害鐩镐技,纾烽吀涓夐挋闄剁摲涓昏涓轰簹寰背绾у瓟闅?鏅剁矑绮掑緞100 nm-1.0渭m,Bio-Oss楠ㄧ矇涓昏涓虹撼绫崇骇瀛旈殭;浣撳鐭垮寲瀹為獙鏄剧ず,纾烽吀涓夐挋闄剁摲琛ㄩ潰璇卞楠ㄧ７鐏扮煶娌夌Н鐨勮兘鍔涘己浜嶣io-Oss楠ㄧ矇;涓嶣io-Oss楠ㄧ矇鐩告瘮,纾烽吀涓夐挋闄剁摲鍙粠鑳庣墰琛€娓呫€佺墰琛€娓呯櫧铔嬬櫧婧舵恫涓惛闄勬洿澶氱殑铔嬬櫧璐?P<0.05);(2)CCK-8瀹為獙鏄剧ず,涓ょ鏉愭枡鍧囦績杩涚粏鑳炲娈?涓ょ粍闂存瘮杈冨樊寮傛棤鏄捐憲鎬ф剰涔?P>0.05);(3)纾烽吀涓夐挋闄剁摲缁勫煿鍏?,7 d鐨勭⒈鎬х７閰搁叾娲绘€ч珮浜嶣io-Oss缁?P<0.05),鍩瑰吇21 d鐨勭熆鍖栫粨鑺傛暟閲忓浜嶣io-Oss缁凔鍩瑰吇7,14 d鐨勭⒈鎬х７閰搁叾銆侀閽欑礌銆侀妗ヨ泲鐧藉強Runx-2鐨刴RNA琛ㄨ揪鍧囬珮浜嶣io-Oss缁?P<0.05);(4)缁撴灉琛ㄦ槑,鏂板瀷纾烽吀閽欓櫠鐡峰叿鏈変紭瓒婄殑浣撳楠ㄨ瀵兼€ц兘銆?..
搴旂敤
搴旂敤
搴旂敤
鐩殑瑙傚療纰抽吀閽欑撼绫崇矑瀛愰澏鍚戝厜鍔ㄥ姏娌荤枟鑳拌吅鐧岀殑鐤楁晥,骞跺鍏朵綔鐢ㄦ満鍒惰繘琛屾帰绱€€傛柟娉曢噰鐢ㄦ皵浣撴墿鏁ｆ硶鍒跺瑁呰浇鍏夋晱鍓備簩姘㈠崯鍚〆6(chlorine e6,Ce6)绾崇背绮掑瓙Ce6@CaCO3,鑱氫箼浜岄唶淇グ鍚?鐗╃悊鍚搁檮鑳板矝绱犳牱鐢熼暱鍥犲瓙1鍙椾綋(insulin-like growth factor 1 receptor,IGF-1R)鐨勯厤浣揕insitinib,鏈€缁堝悎鎴愰吀鍝嶅簲鐨勪富鍔ㄩ澏鍚戝瀷绾崇背绮掑瓙Ce6/Lins@CaCO3-PEG(CLCP),骞惰繘琛岀悊鍖栨€ц川琛ㄥ緛銆傞€氳繃缁嗚優鍜屽姩鐗╁疄楠?瑙傚療CLCP涓诲姩闈跺悜鎬у強鍏夊姩鍔涙不鐤楄儼鑵虹檶鐨勬晥鏋溿€傜粨鏋淐LCP姘村悎绮掑緞涓?121.5卤5.2)nm,鐢甸暅涓嬪憟鍧囧寑鍒嗘暎鐨勭悆褰←CLCP涓瑿e6鐨勫寘灏佺巼涓?3.2%銆佸寘杞界巼涓?6.37%;CLCP鍦ㄩ吀鎬?pH=6.5)鐜涓嬪彲杩呴€熼檷瑙ｃ€傜粏鑳炴憚鍙栧疄楠岃〃鏄庤儼鑵虹檶缁嗚優瀵笴LCP鎽勫彇杈冮潪闈跺悜缁勬槑鏄惧澶?P<0.001);娲?姝荤粏鑳炴煋鑹插強CCK-8瀹為獙琛ㄦ槑,涓庨潪闈跺悜缁勬瘮杈?CLCP鍏夊姩鍔涙不鐤楀悗鑳拌吅鐧岀粏鑳炴椿鍔涙槑鏄句笅闄?P<0.01)銆佹浜″澶?P<0.001)銆侰LCP鍏夊姩鍔涙不鐤楃粍灏忛紶鐢熷瓨鏈熸槑鏄惧欢闀?鐥呯悊鎻愮ず鑲跨槫缁勭粐缁嗚優鍑嬩骸澧炲,涓旀祦寮忕粏鑳炴湳琛ㄦ槑鑲跨槫缁勭粐涓瑿D8+T缁嗚優姣斾緥澧炲ぇ銆傜粨璁烘垚鍔熸瀯寤轰簡鍩轰簬IGF-1R鐨勭⒊閰搁挋绾崇背绮掑瓙CLCP,闈跺悜閫掗€佸厜鏁忓墏Ce6骞朵粙瀵煎厜鍔ㄥ姏娌荤枟鐩存帴鏉€浼よ偪鐦ょ粏鑳炲拰婵€娲绘姉鑲跨槫鍏嶇柅,鏈夋晥鎶戝埗浜嗚儼鑵虹檶鐨勭敓闀?涓鸿儼鑵虹檶鐨勬不鐤楁彁渚涗簡鏂版€濊矾銆?..
搴旂敤
搴旂敤
Copyright漏2002-2025 Cnpowder.com.cn Corporation,All Rights Reserved
