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姝ゅ锛孎e3O4@Dextran NPs澧炲己鐨凷WI閫氳繃涓庡叾浠栧妯℃€佺鍏辨尟搴忓垪鐨勫尮閰嶅垎鏋愶紝鏈夊姪浜庣簿纭弿缁楢IS鍚庣殑缂鸿鏍稿績銆佷晶鏀拰缂鸿鍗婂奖銆侟/p>

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鏂囩尞鍚嶇О锛欬/strong>A Minimalist Iron Oxide Nanoprobe for the High鈥怰esolution Depiction of Stroke by Susceptibility鈥怶eighted Imaging

DOI:10.1002/smll.202401061

Advanced Materials

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2024骞?鏈?4鏃ワ紝Advanced Materials鎶ラ亾鐮旂┒浜哄憳閫氳繃鍏夎仛鍚堜慨楗扮殑閫忔槑璐ㄩ吀锛圙MHA锛変綔涓哄熀璐紝鍦ㄧ緹鍩虹７鐏扮煶鍩虹殑涓┖澶氬瓟纾佹€у井鐞?HAp-Fe3O4)瀛樺湪涓嬶紝鍚堟垚浜嗕竴绉嶆柊鍨嬪鍔熻兘鏀灦锛屾湁鏈涜В鍐宠繖涓棶棰樸€侟/p>

鍐呰蒋楠ㄤ笅楠ㄤ慨澶嶇粨鏋滆〃鏄庯紝璇ユ敮鏋剁殑绮惧績璁捐鍏锋湁鏈€閫傚悎杞涓嬮淇鐨勫睘鎬э紝鏀灦鍐呯鎬у井鐞冪殑澶氬瓟缁撴瀯淇冭繘浜嗚杞界殑澶栨簮鎬ц绠″唴鐨敓闀垮洜瀛愶紙VEGF锛夌殑鏈夋晥浼犺緭锛岀粍瑁呭湪寰悆涓殑Fe3O4绾崇背绮掑瓙淇冭繘楠ㄩ珦闂村厖璐ㄥ共缁嗚優鐨勬垚楠ㄥ垎鍖栵紝骞跺姞閫熸柊楠ㄧ敓鎴愩€侟/p>

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姝ゅ锛岀鍏辨尟鎴愬儚鐩戞祴鏄剧ず锛孎e3O4绾崇背绮掑瓙鍦ㄨ蒋楠ㄤ笅缂洪櫡淇杩囩▼涓€愭笎琚柊楠ㄦ墍鏇夸唬锛屽厑璁告棤鍒涗笖鏃犺緪灏勭殑璇勪及锛屼互璺熻釜OA淇杩囩▼涓柊鐢熼鐨勫彂灞曘€侟/p>

杩欑姘村嚌鑳舵敮鏋堕€氳繃鍏剁鎬ф垚鍍忔晥搴斿疄鐜颁簡杞涓嬮鍜岃蒋楠ㄧ殑闀挎湡浣撳唴璺熻釜锛屾弧瓒充簡涓村簥闇€姹傘€傜粡杩囪繘涓€姝ョ殑鐮旂┒鍜屾敼杩涳紝鏈夋湜鐢ㄤ簬涓村簥搴旂敤銆侟/p>

鏂囩尞鍚嶇О锛欬/strong>A Superparamagnetic Composite Hydrogel Scaffold as In Vivo Dynamic Monitorable Theranostic Platform for Osteoarthritis Regeneration

DOI:10.1002/adma.202405641

Journal of Nanobiotechnology

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2024骞?鏈?3鏃ワ紝Journal of Nanobiotechnology鎶ラ亾鐮旂┒浜哄憳璁捐骞舵垚鍔熷埄鐢ㄤ笁绉嶅甫鏈夊弻鑶﹂吀閰熀鍥絾鍙︿竴绔甫鏈変笉鍚岀鍩猴紙鍗抽槾绂诲瓙銆侀槼绂诲瓙鍜屼袱鎬х瀛愬熀鍥級鐨勫皬鍒嗗瓙閰嶄綋鍖呰瓒呭皬Fe3O4绾崇背绮掑瓙锛岀爺绌朵簡琛ㄩ潰閰嶄綋璋冭妭鐨勮秴灏忕撼绫崇矑瀛愮殑鑲捐剰娓呴櫎琛屼负銆侟/p>

绯荤粺鐮旂┒琛ㄦ槑锛岀敤杩欎簺琛ㄩ潰閰嶄綋淇グ鐨勮秴灏廎e3O4绾崇背绮掑瓙涓嶄粎鍏锋湁瓒冲灏忕殑娴佷綋鍔ㄥ姏瀛﹀昂瀵革紝浣垮叾鑳藉閫氳繃鑲捐剰娓呴櫎锛岃€屼笖杩樿〃鐜板嚭浼樺紓鐨凾1/T2 MRI瀵规瘮澧炲己鎬ц兘銆侟/p>

缁撳悎鑶€鑳盡RI鍜岄€氳繃ICP-OES娴嬪畾鐨勫翱娑睩e鍚噺锛岀爺绌朵汉鍛樺彂鐜颁袱鎬х瀛愰厤浣撳寘瑕嗙殑Fe3O4绾崇背绮掑瓙 (Fe3O4@DMSA) 琛ㄧ幇鍑轰紭寮傜殑鑲捐剰娓呴櫎鐜囷紝杩欐槸鍥犱负鍏惰RES鍚告敹鍑忓皯銆傚€熷姪浜叉按閰嶄綋鐨勪簩纾烽吀鐩愰敋瀹氬熀鍥紝Fe3O4@DMSA 宸叉垚鍔熺敤99mTc鏍囪锛屼粠鑰屽疄鐜伴珮鏁堣偩鑴忓彲娓呴櫎鐨凪RI/SPECT鍙屾ā鎬佹垚鍍忕撼绫虫帰閽堛€侟/p>

鍊煎緱娉ㄦ剰鐨勬槸锛岃繖绉嶇撼绫虫帰閽堝湪4T1寮傜绉绘鑲跨槫灏忛紶妯″瀷涓樉绀哄嚭浠や汉婊℃剰鐨勬垚鍍忚兘鍔涖€傛澶栵紝鐮旂┒浜哄憳杩橀€氳繃瀹夊叏鎬ц瘎浼板疄楠屽Fe3O4@DMSA鐨勭敓鐗╃浉瀹规€ц繘琛屼簡浣撳鍜屼綋鍐呰瘎浼般€侟/p>

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鏂囩尞鍚嶇О锛欬/strong>Surface ligand-regulated renal clearance of MRI/SPECT dual-modality nanoprobes for tumor imaging

DOI:10.1186/s12951-024-02516-2

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鏍规嵁绮掑緞鍙婂舰璨屽垎绫狐/strong>

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