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Graphene as a powerful inorganic material such as excellent conductivity andideal mechanical strength has recently been extensively utilized to developflexible strain sensors. However, graphene-based strain sensors usually sufferfrom the deficiencies of stretchability, sensitivity, and sensing range, whichcan restrict their applications in wearable devices. Here, a novel strain sensoris designed by integrating graphene/ecoflex film and meandering zinc wireinto the flexible base. The constructed strain sensor not only possesses highstretchability of up to 150% strain but can also self-generates current signalsfrom redox-induced electricity, where the stable current and voltage signals ofabout 75µA and 0.83 V can be obtained, respectively. Furthermore, the selfpowered sensor presents a broad and linear sensing range of 25% to 150%strains and a fast response time of less than 0.11 s. Attached on human body,the sensor has been utilized to realize the motion detection of knee joint.