浠嬬粛

鍑濊兌鐨勮幏寰椾富瑕侀€氳繃涓ょ鏈虹悊锛欬/span>

閫氳繃鑱氬悎鐗╃殑缃戠姸鐗╁垱閫犱竴涓綉缁滅粨鏋勶紙渚嬪鏄庤兌锛夛紝鎴栬€呴€氳繃棰楃矑鐨勮仛闆嗘垨绲嚌褰㈡垚缃戠粶缁撴瀯锛堜緥濡傞吀濂讹級銆傚湪鍖栧鍝佸伐涓氫腑锛岀粡甯哥敤鍑濊兌鏉ヨ幏寰椾笉鍚岀殑璐ㄦ劅锛屽悓涓€涓钩娑插嚌鑳跺墠鍚庣殑寰缁撴瀯涔熶細鏄庢樉涓嶅悓锛屽Figure 1銆侟/span>

瀵逛簬閫氳繃绲嚌鎴愬瀷鍑濊兌鐨勪钩娑蹭綋绯伙紝娑叉淮涔嬮棿鐨勭浉浜掍綔鐢ㄤ緷璧栦簬娓╁害銆佹恫婊村昂瀵搞€佺洂娴撳害鍜屼钩娑叉祿搴︾瓑鍥犵礌銆傞厤鏂圭爺鍙戣€呴渶瑕佺煡閬撲钩娑插湪浣曠鏉′欢涓嬪嚭鐜板嚌鑳讹紝涔虫恫鏄惁鏈夊嚌鑳跺寲鐨勮秼鍔匡紝鍑濊兌鐨勭壒寰侊紝鍑濊兌瀛樺湪鐨勬潯浠跺拰绋冲畾鎬э紝绛夌瓑銆傛湰鏂囦腑锛屾垜浠憟鐜颁簡鍑犱釜鍙橀噺瀵逛钩娑插嚌鑳跺寲鐨勫奖鍝嶃€侟/span>

鏂规硶

鐮旂┒浜嗕互SDS锛堝崄浜岀兎鍩虹～閰搁挔锛夊湪CMC娴撳害涓嬬ǔ瀹氱殑涔虫恫鍑濊兌鍖栫幇璞°€傛恫婊村钩鍧囩矑寰勪负1渭m銆侟/span>

鍦ㄧ涓€涓疄楠屼腑锛圏/span>a锛孅/span>b锛孅/span>c锛夛紝鎴戜滑鐮旂┒浜嗚繛缁浉涓洂娴撳害瀵逛钩娑插嚌鑳跺寲鐨勫奖鍝嶃€備钩娑茶瑙ｇ儹鍒?/span>40鈩傸span style="font-family: 瀹嬩綋;">锛岀劧鍚庤浆绉昏嚦Turbiscan LAB涓€侟/span>

鍦ㄧ浜屼釜瀹為獙涓紙d锛孅/span>e锛孅/span>f锛夛紝鎴戜滑鐮旂┒浜嗗垎鏁ｇ浉浣撶Н娴撳害瀵逛钩娑插嚌鑳跺寲鐨勫奖鍝嶃€傚垵濮嬬殑涔崇姸娑叉槸涓€鏍风殑锛屽湪鏀惧叆Turbiscan LAB鍓嶏紝涔虫恫琚姞鐑埌60鈩傸span style="font-family: 瀹嬩綋;">銆侟/span>

缁撴灉

1.鐩愭祿搴?/span>

Figure 2灞曠ず浜嗙洂娴撳害瀵逛钩娑插嚌鑳跺奖鍝嶇殑瀹為獙缁撴灉銆傚皢灏嗕钩娑蹭繚鎸佹俯搴﹀湪45鈩傸span style="font-family: 瀹嬩綋;">锛屽緟娑叉淮寮€濮嬪嚭鐜扮浉浜掍綔鐢ㄧ矘杩炵诞鍑濇椂锛岄€愭笎鍐峰嵈鑷冲娓╋紝浣跨敤Turbiscan Lab鍏ㄧ▼娴嬭瘯銆侟/span>

鍦ㄧ煭鍛ㄦ湡瀹為獙涓紝鍗充粠45鈩傸span style="font-family: 瀹嬩綋;">鍐峰嵈鑷冲娓╂椂锛堜粠鍑濊兌鍖栧垵濮嬫椂鍒昏嚦鍐峰嵈瀹ゆ俯闃舵锛夛紝鎴戜滑瑙傚療鍒版湭鍔犲叆鐩愮殑涔虫恫锛圏/span>sample a锛夊厜寮哄€兼病鏈夋槑鏄惧彉鍖栵紝鍔犲叆0.38M鐩愮殑涔虫恫鑳屾暎灏勫厜寮哄害鍦ㄦ牱鍝佹暣浣撻珮搴︿笂鍧囧寑鐨勪笅闄嶏紙figure 2锛夈€傚浜嶞/span>sample b锛岃繖涓笅闄嶏紙20min锛夋瘮杈冪紦鎱㈠拰娓╁拰锛圏/span>-0.6%锛夛紝浣嗘槸鏍峰搧c锛屼笅闄嶉€熷害杈冨揩锛圏/span>10min锛夊苟涓旀槑鏄撅紙-17%锛夈€傚湪闀垮懆鏈熷疄楠屼腑锛堝喎鍗村悗鐨勯樁娈碉級锛岄櫎浜嗗井灏忕殑涓婃诞鐜拌薄锛岃儗鏁ｅ皠鍏夊苟娌℃湁澶х殑鍙樺寲銆侟/span>

Turbiscan鏁版嵁鏄剧ず鍑濊兌杩囩▼涓叿鏈夋槑鏄剧殑绮掑緞鍙樺寲锛屽彲浠ョ‘瀹氾紝璇ヤ钩娑茬殑鍑濊兌鏄敱浜庣诞鍑濆鑷寸殑銆傚綋鐩愭祿搴﹁緝浣庢椂锛圏/span>b锛夛紝涔虫恫浼氬舰鎴愬皬鐨勭诞鍑濓紝瀵瑰簲鐫€鑳屾暎灏勫厜杞诲井鐨勪笅闄嶃€傚綋鐩愭祿搴﹀鍔犳椂锛圏/span>c锛夛紝娑叉淮涔嬮棿鐨勭诞鍑濆彉寰楁洿鍔犲己鐑堬紝鐢熸垚鏇村ぇ鐨勭矑瀛愬昂瀵革紝骞朵娇寰楄儗鏁ｅ皠鍏夊己鍊煎墽鐑堜笅闄嶃€侟/span>

2.浣撶Н娴撳害

濡侟/span>Figure 3鎵€绀猴紝褰撴补浣撶Н娴撳害=1%鏃讹紙d锛夛紝鎴戜滑瑙傚療鍒颁钩娑茬殑鑳屾暎灏勫厜寮哄€煎苟浠讳綍鏄庢樉鐨勫彉鍖栥€傚彟涓€鏂归潰锛屽浜庝钩娑秉/span>e鍜孅/span>f锛岃儗鏁ｅ皠鍏夊己鍊煎湪鐭懆鏈熷唴鍙戠敓鏄庢樉鐨勪笅闄嶏紝浣嗘槸涓嬮檷绋嬪害涓庝綋绉祿搴︿笉鎴愭姣旓紙桅 = 10 %鍜孅/span>20%瀵瑰簲鐨勪笅闄嶇▼搴﹀垎鍒槸-19%鍜孅/span> -14%锛夈€傚厜寮虹殑涓嬮檷瀵瑰簲鐫€涔虫恫娑叉淮灏哄鐨勫鍔犮€侟/span>Turbiscan鏁版嵁鏄剧ず闅忕潃浣撶Н娴撳害澧炲姞锛孅/span>BS涓嬮檷绋嬪害闄嶄綆锛屾剰鍛崇潃楂樻祿搴︿钩娑茬敓鎴愮殑绲嚌灏哄杈冨皬銆備簨瀹炰笂涔熸槸濡傛锛岄殢鐫€娌圭浉浣撶Н娴撳害瓒婇珮锛岀诞鍑濇恫婊村舰鎴愮殑鍑濊兌缁撴瀯鍙嶈€屾洿鍔犺嚧瀵嗐€侟/span>

涓庨鏈熺殑瀹為獙鐜拌薄涓€鑷达紝鍑濊兌鍦ㄩ暱鍛ㄦ湡瀹為獙鍐呰繕鍏锋湁鑴辨按鏀剁缉鐜拌薄銆傛垜浠湪Figure 4涓睍鐜颁簡涓嶅悓娴撳害鐨勪钩娑插嚌鑳剁殑鑴辨按鏀剁缉閲忋€傝繖浜涙洸绾挎樉绀哄彧鏈変钩娑叉祿搴﹀湪30%鏃讹紝鍑濊兌浼氬舰鎴愮ǔ瀹氱姸鎬侊紝鍏惰劚姘存敹缂╀綔鐢ㄥ湪1h涔嬪悗瀹屾垚锛岃€屽叾浠栫殑涔虫恫鏃犳硶绋冲畾浼氬嚭鐜颁笂娴€侟/span>

缁撹

SDS涔虫恫浣撶郴鍦ㄧ洂娴撳害鍜屾俯搴︽潯浠朵笅锛屾恫婊翠箣闂翠細鐩镐簰绲嚌褰㈡垚鍑濊兌銆傚綋娌圭浉浣撶Н娴撳害鍚噺杈惧埌30%鍚庯紝鍙互褰㈡垚绋冲畾鐨勪钩娑插嚌鑳躲€侟/span>Turbiscan瀵逛钩娑插嚌鑳跺舰鎴愯繃绋嬪彲浠ュ悓鏃跺畾鎬у拰瀹氶噺锛岄潪甯搁€傜敤浜庤繖浜涙柊鏉愭枡鐨勮〃寰佸拰鐨勪紭鍖栭厤鏂广€侟/span>

Formulaction

绋冲畾鎬у垎鏋愪华Turbiscan AGS

涓撲负澶ф壒閲忕爺鍙戦儴闂ㄥ拰璐ㄦ閮ㄩ棬璁捐銆侟/span>TurbiScan Lab涓庡叏鑷姩鏈烘鎵嬬殑瀹岀編缁撳悎銆傚叏鑷姩鏈烘鎵嬪寘鎷?/span>3涓嫭绔嬬殑鎭掓俯妲藉拰涓€涓牱鍝佽緭閫佺殑鏈烘鑷傘€傛瘡涓亽娓╂Ы涓湁18涓牱鍝佹Ы锛屼竴鍏卞彲浠ュ瓨鍌?/span>54涓牱鍝佷緷娆℃祴閲忋€傛亽娓╂Ы娓╁害鎺у埗浠庡娓?/span>+5鈩傸span style="font-family: 瀹嬩綋;">鍒?/span>60鈩傸span style="font-family: 瀹嬩綋;">锛屾牱鍝佽緭閫佺殑鏈烘鑷傛瘡灏忔椂杩愯60娆★紝鍙繛缁?/span>7澶╀笉闂存柇宸ヤ綔銆侟/span>