
2023/03/07 闃呰锛?19
鏂规鎽樿
2鏈?2鏃ワ紝鍖椾含甯傜柧鎺т腑蹇冨彂甯冩秷鎭紝褰撳墠鍖椾含甯傛祦琛岀殑娴佹劅鐥呮瘨涓紝鐢插瀷娴佹劅鐥呮瘨鎰熸煋鍗犵粷瀵逛紭鍔匡紝鍏朵腑鐢插瀷H1N1浜氬瀷鍗?4%锛岀敳鍨婬3N2鍗?5%锛屼箼鍨嬫祦鎰熷崰1%銆傛嵁鏌愭悳绱㈡寚鏁帮紝杩戜竷鏃ヤ互鏉ワ紝鈥滅敳娴佲€濈殑鎼滅储鍙婃姤閬撻噺鍛堟樉钁椾笂鍗囪秼鍔匡紝浠?鏈?4鏃ワ紝灏辨湁69417鐨勬悳绱㈤噺銆侟sup> [1,2]鐢叉祦妯锛屾帴绉嶆祦鎰熺柅鑻楀彲棰勯槻鐢插瀷娴佹劅銆
鐩墠,鐢叉祦鐤嫍涓昏鏈変笁绉嶇被鍨嬶細鍏ㄧ梾姣掔伃娲荤柅鑻楋蓟Influenza Vaccine锛圵hole Virion锛?Inactivated锛汭nfV-W锛姐€佽瑙g伃娲荤柅鑻楋蓟Influenza Vaccine锛圫plit Virion锛夛紝Inactivated锛汭nfV-Sp锛藉拰浜氬崟浣嶇伃娲荤柅鑻楋蓟Influenza Vaccine锛圫ubunit锛夛紝Inactivated锛汭nfV-Su锛界瓑銆傛牴鎹柅鑻楃敓浜ф槸鍚﹀姞鍏ヤ綈鍓傦紝鍙堝垎涓烘湁/鏃犱綈鍓傜柅鑻椼€傛祦鎰熺柅鑻楃爺绌朵腑搴旂敤鍒扮殑浣愬墏涓昏鏈夐摑浣愬墏锛堟哀鍖栭摑銆佹阿姘у寲閾濄€佺7閰搁摑锛夈€丮F59銆丩TK63銆佹柊鍨嬩綈鍓傜瓑锛岀敳娴佺柅鑻楀父鐢ㄧ殑浣愬墏涓洪摑浣愬墏銆侟sup>[3,4]
涓€銆 閾濅綈鍓傜矑寰勬娴婞/strong>
閾濅綈鍓傛槸绗竴涓鎵瑰噯鐢ㄤ簬浜轰綋鐨勭柅鑻椾綈鍓傦紝鐢ㄤ簬澧炲姞鏈轰綋瀵逛簬鐤嫍鐨勫弽搴旓紝鐗瑰埆鏄寮烘姉浣撶殑浜х敓锛屾敼鍠勭敱浜庡勾榫勩€佺柧鐥呮垨鍏朵粬鍘熷洜瀵艰嚧鐤嫍鍙嶅簲鑳藉姏闄嶄綆鐨勯棶棰樸€傚湪鍏嶇柅杩囩▼ 涓紝閫氳繃灏嗘姉鍘熷惛闄勫埌浣愬墏涓婏紝浣垮緱鎶楀師琚惡杞借繘鍏ユ満浣撲粠鑰岃瀵间骇鐢熷厤鐤簲绛斻€傞噰鐢ㄩ摑浣愬墏绫诲瀷锛屽線寰€浼氱敤姘㈡哀鍖栭摑鎴栬€呯7閰搁摑銆傛阿姘у寲閾濇槸涓€绉嶈〃闈㈠彧鏈夌緹鍩哄熀鍥㈢殑灞傜姸鏅朵綋锛屼互绾ょ淮绮掑瓙褰㈠紡瀛樺湪锛岃繖绉嶇矑瀛愯仛闆嗗悗浠ユ澗鏁g殑褰㈠紡瀛樺湪锛屽ぇ灏忕害1-10渭m锛屽彧鏈変綈鍓傞绮掔殑澶栧眰鍙互鍜屾姉鍘熺粨鍚堛€傜7閰搁摑浣愬墏鏄緹鍩虹7閰搁摑澶嶅悎鐗╋紝涓烘棤瀹氬舰缁撴瀯锛屽垵濮嬮绮掔殑鏄洿寰勪负50nm鐨勭洏鐘剁粨鏋勶紝鐒跺悗褰㈡垚澶х害3渭m宸﹀彸鐨勬澗鏁g矑瀛愩€
褰卞搷閾濅綈鍓傚簲绛斿弽搴旂殑鍥犵礌鍖呮嫭鎶楀師浣愬墏鐨勫惛闄勭巼銆佸惛闄勫己搴︺€佷綈鍓傞绮掑ぇ灏忓強鍧囦竴鎬э紝鍏朵腑浣愬墏棰楃矑澶у皬鍙奖鍝嶅鎶楀師鐨勬彁鍙栥€佽浆杩愬強涓庢姉鍘熺浉浜掍綔鐢ㄣ€侟sup>[5]姝ゅ锛岃繕闇€鍏虫敞杩囧皬鐨勯绮掓祿搴︼紝濡傛灉杩囧皬棰楃矑娴撳害杩囧锛屽浣庝簬100nm锛屽嚑鍗佺撼绫冲乏鍙筹紝閭d箞娉ㄥ叆浣撳唴鍚庡彲浠ョ┛杩囦汉浣撳唴澶ч儴鍒嗙粏鑳炲睆闅滐紝鍒拌揪鐨勪汉浣撻儴浣嶆洿澶氭洿骞匡紝鐢辨閫犳垚鐨勬瘨鍓綔鐢ㄤ細澧炲姞銆傚湪鍘诲勾锛岃緣鐟炲洟闃熸挵鍐欑殑鍏充簬銆婇摑浣愬墏鐤嫍鐨勬偓娑叉€ц川鍙婅〃寰併€嬬珷鑺備腑锛屼篃鎻愬埌浜嗛€氳繃LumiSpoc鍏虫敞灏忛绮掓祿搴︺€侟sup>[6]
鐤嫍鍦ㄥ疄闄呭簲鐢ㄨ繃绋嬩腑锛屽父鐢ㄥ喎钘忔柟寮忎繚鎶ょ柅鑻楀厤浜庨珮娓╃牬鍧忥紝浣嗕篃鏈変娇鐤嫍鏆撮湶浜庤繃浣庢俯搴︾殑椋庨櫓銆傚惈閾濅綈鍓傜殑鐤嫍鍦ㄧ粡鍐峰喕鍚庢晥浠烽檷浣庢槑鏄俱€傛甯告儏鍐典笅锛屼綈鍓備笌鎶楀師缁撳悎鍦ㄤ竴璧枫€傚喕铻嶅悗锛屼綈鍓備笌鎶楀師涔嬮棿鐨勭粨鍚堥敭浼氳鐮村潖锛屽鑷翠綈鍓備笌鎶楀師鑴辩銆傚垎绂荤殑浣愬墏锛屼細閫愭笎鑱氶泦锛屽舰鎴愯緝澶ц緝閲嶇殑棰楃矑锛屽苟鎱㈡參娌夋穩浜庡簳閮ㄣ€傚け鍘讳綈鍓傜殑鎶楀師锛屽厤鐤師鎬уぇ澶ч檷浣庛€佸厤鐤晥鏋滃ぇ鎵撴姌鎵o紝鐤嫍涔熷氨澶卞幓浜嗗簲鏈夌殑棰勯槻浣滅敤銆傚悓鏃讹紝娓哥浣愬墏褰㈡垚鐨勫ぇ棰楃矑鐗╄川锛岃繕浼氬鑷村厤鐤壇鍙嶅簲鐨勫彂鐢熷嚑鐜囧崌楂楛sup>[7]銆傚洜姝わ紝瀵逛簬閾濅綈鍓傚ぇ棰楃矑鐨勭洃鎺э紝澶ч绮掔殑鎺у埗涔熸槸绋冲畾宸ヨ壓鍜岄伩鍏嶄笉鑹弽搴旂殑鐩戞帶瑕佺偣銆侟/span>
AccuSizer棰楃矑璁℃暟鍣ㄧ郴鍒桙/span>
AccuSizer绯诲垪鍦ㄦ娴嬫恫浣撲腑棰楃矑鏁伴噺鐨勫悓鏃剁簿纭娴嬮绮掔殑绮掑害鍙婄矑搴﹀垎甯冿紝閫氳繃鎼厤涓嶅悓浼犳劅鍣ㄣ€佽繘鏍峰櫒锛岄€傞厤涓嶅悓鐨勬牱鏈殑娴嬭瘯闇€姹傦紝鑳藉揩閫熻€屽噯纭湴娴嬮噺棰楃矑绮掑緞浠ュ強棰楃矑鏁伴噺/娴撳害銆侟/span>
鈿?/span> 妫€娴嬭寖鍥翠负0.5渭m-400渭m锛堝彲灏嗕笅闄愭嫇灞曡嚦0.15渭m锛夈€侟/span> 鈿?/span> 0.01渭m鐨勮秴楂樺垎杈ㄧ巼锛孉ccuSizer绯诲垪鍏锋湁1024涓暟鎹€氶亾锛岃兘鍙嶆槧澶嶆潅鏍峰搧鐨勭粏寰樊寮傦紝涓虹爺鍙戝強鍝佹帶淇濋┚鎶よ埅銆侟/span> 鈿?/span> 鐏垫晱搴﹂珮杈?0PPT绾у埆锛屽嵆浣垮彧鏈夊井閲忕殑棰楃矑閫氳繃浼犳劅鍣紝涔熷彲浠ョ簿鍑嗘娴嬪嚭鏉ャ€侟/span> 鈿?/span> 鍙嚭鍏锋硶瑙勬姤鍛夵/span> |
LumiSpoc 鍗曠矑瀛愰绮掕鏁板櫒
LumiSpoc閲囩敤鍗曠矑瀛愬厜鏁e皠鎶€鏈紙SPLS锛夛紝閫氳繃鍦ㄥ厜瀛︽祦閫氭睜涓繘琛屾祦浣撳姩鍔涜仛鐒︼紝灏嗗崟涓矑瀛愭帓鍒楁垚涓€鏉$洿绾裤€傞€氳繃璋冩暣娴佸姩鏉′欢鏉ヨ皟鏁存牱鍝佹祿搴︼紝浠庤€岄伩鍏嶆祿搴﹀嘲鍊肩殑褰卞搷銆傚綋鍗曚釜绾崇背鎴栬€呭井绫抽绮掔粡杩囩壒娈婂厜鏉熸埅闈㈢殑婵€鍏夋潫鏃讹紝璁板綍鍏舵鍚戝拰渚у悜鏁e皠鐨勫厜寮恒€傛牴鎹背姘忕悊璁猴紝灏嗗垎绫诲己搴﹁浆鎹负绮掑害鍒嗗竷瀵嗗害銆傞€氳繃杞欢鍒嗘瀽鏄剧ず璁℃暟鍒嗗竷銆侀绮掓祿搴︺€傚湪琛屼笟鍐呭凡鏈変娇鐢↙umispoc鐢ㄤ簬棰楃矑娴撳害鐨勭洃娴嬫垚鍔熸渚嬨€侟/span>
鈿?/span> 棰楃矑绮掑緞妫€娴嬭寖鍥达細50 nm ~ 8 µm锛堝彇鍐充簬鏍峰搧锛堻/span> 鈿?/span> 棰楃矑娴撳害妫€娴嬭寖鍥达細1 脳 106ml-1~ 1 脳 109ml-1 鈿?/span> 杩涙牱浣撶Н锛?50 渭l |
浜屻€侀摑浣愬墏瀹夊叏鎬ф帶鍒迭/strong>
閾濅綈鍓備腑鐨勬潅璐ㄤ細褰卞搷閾濅綈鍓傜殑瀹夊叏鎬э紝閾濅綈鍓傛墍鐢ㄧ殑鐢熶骇鏉愭枡涓€鑸负鏃犳満鐩愶紝閾濅綈鍓備腑鎵€鍚潅璐ㄥ彲鑳界敱鍘熸潗鏂欏紩鍏ワ紝涔熷彲鑳藉湪鐢熶骇杩囩▼涓骇鐢燂紝鏈€缁堝彲琚甫鍏ヨ嚦涓嬫父鍚勯樁娈典骇鐗╀腑銆傚洜姝ゅ簲鑰冭檻璁剧疆鐩稿叧宸ヨ壓姝ラ鍘婚櫎鏉傝川锛屽苟瀵瑰叧閿敓浜у弬鏁般€佽繃绋嬫帶鍒躲€佸弽搴斿鍣ㄧ瓑澶氭柟闈㈣繘琛屽厖鍒嗛獙璇併€侟/span>
Entegris-ANOW 婊よ姱
Entegris-Anow鏄竴瀹堕珮鍒嗗瓙寰瓟鑶滆繃婊や紒涓氾紝涓撲笟浠庝簨MCE銆丯ylon銆丳ES銆丳VDF銆丳TFE绛夛紙鑶滃瓟寰勪负0.03渭m~10渭m锛夊井瀛旇啘鐨勭爺鍙戝強鐢熶骇锛屽叿鏈変簩鍗佸骞存湇鍔′笌鍖昏嵂瀹㈡埛缁忛獙锛屽苟涓哄叏鐞冪敓鐗╁埗鑽€佸尰鐤楀櫒姊般€侀鍝侀ギ鏂欍€佸疄楠屽鍒嗘瀽銆佸井鐢靛瓙鍙婂伐涓氱瓑棰嗗煙鐨勫鎴锋彁渚涜繃婊ゃ€佸垎绂诲拰鍑€鍖栬В鍐虫柟妗堛€
Entegris涓嶢now鐨勭粨鍚堬紝寮曞叆Entegris璐ㄩ噺绠$悊浣撶郴锛屾瘡涓€鏀护鑺兘缁忚繃涓ユ牸妫€鏌ワ紝姝ゅ锛屾柊寤烘垚鐨凜TC楠岃瘉涓績锛屼负鍏ㄧ悆瀹㈡埛鎻愪緵涓撲笟鐨勯獙璇佹湇鍔°€侟/span>
鍙傝€冩枃鐚細
[1] 婢庢箖鏂伴椈
[2] 寮犱紵浼?鏉庝寒,鏈卞嚖鎵?淇粫淇?鐢插瀷H_1N_1娴佽鎬ф劅鍐掔柅鑻楃爺绌惰繘灞曞強涓嶈壇鍙嶅簲鐩戞祴[J].
[3] 涓浗鐤嫍鍜屽厤鐤?2010,16(03):275-278.
[4] 椹幆,姹繍娲?鐜媍hen,鐜嬬彛,鍛ㄧ,闄堝叴,娼樻捣榫?绾崇背姘㈡哀鍖栭摑浣愬墏鐨勫埗澶囧強鍏剁浉鍏虫€ц川鍒嗘瀽
[5] 涓浗鐢熺墿鍒跺搧瀛︽潅蹇?2022,35(09):1107-1111.
[6] Langford, A., Bruchsaler, M., & Gupta, M. (2022). Suspension properties and characterization of aluminum-adjuvanted vaccines. Practical Aspects of Vaccine Development.
[7] 闄堝┓濠? 闄嗕紵鏍? 閾濅綈鍓傜壒鎬у強鍏剁爺绌惰繘灞昜J]. 涓栫晫涓村簥鑽墿, 2015(2):7.
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